Blood: The Last Vampire is an original Japanese anime film produced by Production I.G and Aniplex (formerly known as SPE Visual Works) and directed by Yukio Nagasaki.
The film is set in the period of post-WWII Japan, in the 1960s. Protagonist Saya is the last "original" vampire. The day of Halloween, Saya hunts down other vampire-monsters (aka chiropterans) with her katana. She goes undercover as a high school student, assigned to a school next to the American Yokota military base by a secret government agency who's sole purpose is to kill all Chiropterans.
Animated bloodily and beautifully well, Blood: The Last Vampire (2000) is known as the first Japanese anime to use a blend of 2-D and 3-D animation, and is credited for creating the "new standard of animation" by using this technique.
Blood: The Last Vampire (2000) has had other spin-off series spawn off its story, with Blood+ (2005), Blood-C (2011) and a handful of video games in partnership with Sony. A live-action adaptation later released in 2009, starring Korean actress Jun Ji Hyun as Saya.
Runtime: 50 min.