Based on the biblical story of Adam and Eve's first two sons, Cain and Abel is about Cain's jealousy towards his brother Abel. Lee Cho-in is a very gifted doctor who has everything that he wants whereas his older brother, Seon-woo, is jealous of all the attention that Cho-in receives. Seon-woo blames his brother for taking everything good in his life away from him: getting their father's love, getting more recognition as a doctor, and for stealing the woman he loves.
AWARDS
| Year | Award | Category | Recipient |
| 2009 | Grimae Awards | Best Actor | So Ji-sub |
| 2009 | Ministry of Culture, Sports and Tourism | Actor of the Year in Broadcasting | So Ji-sub |
| 2009 | SBS Drama Awards | Top 10 Stars | So Ji-sub |
| 2009 | SBS Drama Awards | Best Supporting Actor in a Drama Special | Baek Seung-hyeon |
| 2009 | SBS Drama Awards | Top Excellence Award, Actor | So Ji-sub |
