The title refers to a local saying that rare diseases are like quizzes God gives to humans so as not to become too arrogant. The first season dealt mostly with inherited rare diseases including porphyria, phenylketonuria, muscular dystrophy, Guillain–Barré syndrome, reflex anoxic seizures and Savant syndrome. Fabry disease, Kleine–Levin syndrome and congenital insensitivity to pain with anhidrosis were featured in the second season.
